A medical device intended for contact with living tissue comprises a substrate having a surface which surface comprises a layer comprising one or more compound(s)of at least one non toxic post transition metal such as a gallium or bismuth compound.A layer comprising a compound of at least one non toxic post transition metal has been shown to inhibit biofilm formation on the surface of the medical device which may reduce the risk for infection e.g. around a dental implant. A method of producing the medical device comprises: a) providing a substrate having a surface； and applying a compound of at least one non toxic post transition metal onto said surface to form a layer e.g. using a thin film deposition technique.
