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新型5H-吡咯並[2,3-D]嘧啶-6(7H)-酮衍生物
专利权人:
TAIHO PHARMACEUTICAL CO., LTD.;大鵬藥品工業株式會社
发明人:
SUGIMOTO Tetsuya,SAKAMOTO Toshihiro,YAMAMOTO Fuyuki,KOBAYAKAWA Yu,EGASHIRA Naoki,ICHIKAWA Koji,MACHIDA Takumitsu,小早川優,EGASHIRA Naoki,江頭直樹,ICHIKAWA Koji,市川幸司,MACHIDA Takumitsu,町田卓充
申请号:
HK19101800
公开号:
HK1259613A1
申请日:
2019.01.31
申请国别(地区):
HK
年份:
2019
代理人:
摘要:
The invention of the present application provides a compound represented by Formula (I) or a salt thereof, which exhibits an inhibitory activity against at least one kinase selected from the group consisting of Akt kinase, Rsk kinase, and S6K kinase and/or a cell proliferation inhibiting effect and is useful as a prophylactic and/or therapeutic agent for diseases associated with the above-mentioned kinases, particularly cancer. [In the formula, R 1 represents a 4- to 6-membered monocyclic unsaturated heterocyclic group which has 1 to 3 hetero atoms independently selected from N, S and O and may have a substituent; R 2 represents a hydrogen atom or the like; R 3 , R 4 , and R 5 , may be the same as or different from one another and independently represent a hydrogen atom or the like; R 6 represents a hydrogen atom or the like; R 7 and R 8 , may be the same as or different from each other and independently represent a hydrogen atom or the like; X 1 and X 2 may be the same as or different from each other and independently represent N or CR 9 ; R 9 represents a hydrogen atom or the like; and X 3 represents N or CH when the broken line ( ----- ) represents a single bond, and represents C when a broken line indicates a double bond, wherein at least one of X 1 or X 2 represents N.]
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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