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NEUARTIGES 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ON-DERIVAT
专利权人:
Taiho Pharmaceutical Co.; Ltd.
发明人:
SUGIMOTO Tetsuya,SAKAMOTO Toshihiro,YAMAMOTO Fuyuki,KOBAYAKAWA Yu,EGASHIRA Naoki,ICHIKAWA Koji,MACHIDA Takumitsu
申请号:
EP17799511
公开号:
EP3459953A4
申请日:
2017.05.19
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
The invention of the present application provides a compound represented by Formula (I) or a salt thereof, which exhibits an inhibitory activity against at least one kinase selected from the group consisting of Akt kinase, Rsk kinase, and S6K kinase and/or a cell proliferation inhibiting effect and is useful as a prophylactic and/or therapeutic agent for diseases associated with the above-mentioned kinases, particularly cancer. [In the formula, R 1 represents a 4- to 6-membered monocyclic unsaturated heterocyclic group which has 1 to 3 hetero atoms independently selected from N, S and O and may have a substituent; R 2 represents a hydrogen atom or the like; R 3 , R 4 , and R 5 , may be the same as or different from one another and independently represent a hydrogen atom or the like; R 6 represents a hydrogen atom or the like; R 7 and R 8 , may be the same as or different from each other and independently represent a hydrogen atom or the like; X 1 and X 2 may be the same as or different from each other and independently represent N or CR 9 ; R 9 represents a hydrogen atom or the like; and X 3 represents N or CH when the broken line ( ----- ) represents a single bond, and represents C when a broken line indicates a double bond, wherein at least one of X 1 or X 2 represents N.]
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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