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NOVEL 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE DERIVATIVE
专利权人:
TAIHO PHARMACEUTICAL CO.; LTD.
发明人:
SUGIMOTO Tetsuya,SAKAMOTO Toshihiro,YAMAMOTO Fuyuki,KOBAYAKAWA Yu,EGASHIRA Naoki,ICHIKAWA Koji,MACHIDA Takumitsu
申请号:
PH12018502411
公开号:
PH12018502411A1
申请日:
2018.11.15
申请国别(地区):
PH
年份:
2019
代理人:
摘要:
The invention of the present application provides a compound represented by formula (I) or a salt thereof, which exhibits an inhibitory activity against at least one kinase selected from the group consisting of Akt kinase, Rsk kinase and S6K kinase and/or a cell proliferation inhibiting effect and is useful as a prophylactic and/or therapeutic agent for diseases associated with the above-mentioned kinases, particularly cancer. [In the formula, R1 represents a 4- to 6-membered monocyclic unsaturated heterocyclic group which has 1 to 3 hetero atoms independently selected from N, S and O and may have a substituent; R2 represents a hydrogen atom or the like; R3, R4 and R5 may be the same as or different from one another and independently represent a hydrogen atom or the like; R6 represents a hydrogen atom or the like; R7 and R8 may be the same as or different from each other and independently represent a hydrogen atom or the like; X1 and X2 may be the same as or different from each other and independently represent N or CR9; R9 represents a hydrogen atom or the like; and X3 represents N or CH when the broken line (---) represents a single bond, and represents C when the broken line represents a double bond; wherein at least one of X1 and X2 represents N.]
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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