Solomon Langermann;Linda Liu;Shannon Marshall;Sheng Yao
发明人:
Solomon Langermann,Linda Liu,Shannon Marshall,Sheng Yao
申请号：
US14111402
公开号：
US20140044738A1
申请日:
2012.04.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to B7-H1 or PD-1. In some embodiments such molecules are additionally capable of modulating the ability of B7-H1 or B7-DC to bind to PD-1 or are capable of affecting the signaling activity of the B7-H1 or PD-1. The invention additionally concerns the uses of such molecules in the diagnosis and treatment of cancer and other diseases.
