SOLOMON LANGERMANN,LINDA LIU,SHANNON MARSHALL,SHENG YAO
申请号：
PT12774724
公开号：
PT2699264T
申请日:
2012.04.19
申请国别(地区):
PT
年份:
2018
代理人:
摘要：
The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to B7-H1 or PD-1. In some embodiments such molecules are additionally capable of modulating the ability of B7-H1 or B7-DC to bind to PD-1 or are capable of affecting the signalling activity of the B7-H1 or PD-1. The invention additionally concerns the uses of such molecules in the diagnosis and treatment of cancer and other diseases.
