GALATSIS, PAUL,HAYWARD, MATTHEW MERRILL,KORMOS, BETHANY LYN,WAGER, TRAVIS T.,ZHANG, LEI,HENDERSON, JACLYN LOUISE,KURUMBAIL, RAVI G.,VERHOEST, PATRICK ROBERT,STEPAN, ANTONIA FRIEDERIKE
申请号：
CA2933767
公开号：
CA2933767C
申请日:
2014.12.03
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides novel 3,4-disubstituted-1 H-pyrrolo[2,3- Jb]pyridine derivatives and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazine derivatives of Formula (I), and the pharmaceutically acceptable salts thereof (I) wherein R1, R2, R3, R4 and X are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of formula (I) and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinsons disease or Alzheimers disease, cancer, Crohns disease or leprosy.
