Paul Galatsis,Matthew Merrill Hayward,Bethany Lyn Kormos,Travis T. Wager,Lei Zhang,Antonia Friederike Stepan,Jaclyn Louise Henderson,Ravi G. Kurumbail,Patrick Robert Verhoest
申请号：
US14840528
公开号：
US09642855B2
申请日:
2015.08.31
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides novel 4,5-disubstituted-7H-pyrrolo[2,3-d]pyrimidine derivatives of Formula I, and the pharmaceutically acceptable salts thereofwherein R1, R2, R3, R4 and R5 are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.
