4–(מותמר–אמינו)–7h–פירולו[3–2,d]פירימידינים כמעכבי lrrk2

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专利权人:

PFIZER INC.

发明人:

申请号：

IL23629414

公开号：

IL236294A

申请日:

2014.12.15

申请国别(地区):

IL

年份:

2016

代理人:

摘要：

The present invention provides novel 4,5-disubstituted-7 H -pyrrolo[2,3- d ]pyrimidine derivatives of Formula I, and the pharmaceutically acceptable salts thereof wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.

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