Claim 1: Compounds with a formula structure (1),A. or a salt that can be accepted or dissolved by a drug, in which ring A is a compound selected from the formulation group (2)；R1 is a compound selected from the formula group (3)；Z is O, S, C (= O).N(R831222),O C (R8313) 83222；X is O S, R 2 is cycloquilo C8332331；R3 unite is selected from a group of hydrogen, tar C832183832626；E. Cycoal Quilo C8332331832626；Each r830808 was selected independently from a group composed of hydrogen, halogen and C83218331832626 matrix.E. Cycoal Quilo C8332331832626；Or R83088 and R2R3,O R 830808,Together with the attached atoms, they form a ring consisting of five to six members, one or two heteroatoms selected from O, N and S, five to six of which are ring-saturated, unsaturated or aromatic, and five to six of which are optional rings. E was replaced by one, two or three alternatives (C83218331832626) selected from the halo group.- C83218C83331-832626-Oh, Halogalo C8321833126；Cyoquilo C83238C83318328；Heterosexual circulation C832283331；Arilo C832628331-8321； 8320；A. Heterosexuality；- C(= O) R8308；- C(= O) Or 3,- C(= O) N (r1) 832222；- S(= O) R8308；- S(= O) 8322； R1 3,- S(=O) 832222-N (R1 3) 832222；- N(R1 3)832222,- N (R1 cubic meters) C (= O) R18308；Y-N (R1 cubic) s (= O) 8322； r3；E. Each r83099 does not consider a group composed of halogens and hydrocarbons C83218331832626；R8309； 74919 were selected from hydrogen and tar groups.Each R2 83099 is independent of a group of halogens - CN-oh-Or8310；- SR8310；- S(= O) R8311；- No. 8322；- N (R8310) 8322；- S(= O) 8322； R8311；- NHS (= O) 83222； R8311；- S(= O) 8322； (R8310A) 8322；- C(= O) R8311；- C(= O) Or8310A,- OC (= O) R8311；- C(= O) N (R8310) 8322；- OC (= O) N (R8310A) 832222；- No. 8310； (= O) N (R8310A) No. 832222；- No. 8310； (= O) R8311；- No. 8310； (= O) No. 18310；1. C83218331 and 832626 leased land；Alquenilo C83228331-832626；1.C 83228331 asphalt；Cyoquilo C83238C83318328；Heterosexual circulation C832283331；Arilo C832628331-8321； 8320；A. Hete
