PANARESE, JOSEPH,OR, YAT SUN,CHONG, KATHERINE,BARTLETT, SAMUEL
申请号：
ARP190100183
公开号：
AR114234A1
申请日:
2019.01.21
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
This table shows the formula compound (1),They inhibit the protein encoded by hepatitis B virus (HBV) or interfere with the life cycle of hepatitis B virus Hexabromodiphenyl, and can also be used as antiviral agents. This document also covers pharmaceutical compounds including the above compounds.The first two injections were given to a person infected with Hexabromodiphenyl The current situation is also related to the treatment of Hexabromodiphenyl infection in one subject by managing the pharmaceutical components of existing compounds. Claim 1: compound represented by formula (1)O acceptable salt, among which R1 is hydrogen, halogen or c83833183326263； R2 is hydrogen, halogen, CN, alternative c8383316c833266cxi or c831833183318326； a is cyclocyclo c833238331218321； c8328322832183228c21； Alternative, 3-to-12-optional replacement ring, optional replacement ring or optional replacement ring； R 3 selected from R1,-Or1，-SR1，Y-NR1；R83088ES HALO，CN，R1，-Or1，-SR1，O-NR1；When R1 appears, hydrogen is selected independently, c8321s 8331832626 tar；Alternative text C 83228331832626；Alternative, cycloquilo c83231；Alternative, 1 cyclopropene-c83231；a. Optional replacement and heterocyclic ring 3-A 7-optional replacement member； R selected from c8321833231 hydrogen and tar； or In addition, R 3 and r8308 are bound together with carbon atoms to form a 3-A 7-alternative heterocyclic ring； in the other hand, R 3 and r8308 are bound together with carbon atoms to form c8332383318327 selectively replaced ring； 3-to 7-optional replacement of different rings, optional replacement of arilo or optional replacement of different rings；O R3 and r83088 are added together to form a c83135833225 alternative tar； r83099 is hydrogen, halogen, c8318331832625 alternative tar or alcox c8321831832626；a. R8310s was hydrogen, halogen, c8318331832626 or alcox c8332183318331833262； r8311s was hydrogen or c8383316c26； r831222 was selective substitution for hydrogen, halogen, c83318331318326 or alcoxic c833212
