VARIANTES DE L'INTERFÉRON ALPHAA2B

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专利权人:

Teva Pharmaceuticals Australia Pty Ltd

发明人:

申请号：

EP15854166.4

公开号：

EP3212216A4

申请日:

2015.10.23

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention provides a fusion polypeptide comprising a first domain and a second domain, wherein the first domain comprises a polypeptide ligand which binds to a cell surface-associated antigen and the second domain comprises aglycosylated interferon α 2b (IFNα2b) having a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. The aglycosylated IFNα2b further comprises one or more amino acid substitutions or deletions which attenuate the activity of the aglycosylated IFNα2b.

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