Wu, Xihan,Nettekoven, Matthias,Knust, Henner,Ratni, Hasane,Han, Bo
申请号：
AU2008258665
公开号：
AU2008258665B2
申请日:
2008.05.29
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to a compound of formula (I) wherein Ris hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, loweralkoxy, or lower alkoxy substituted by halogen； R is hydrogen or loweralkyl； R, R form together with the N-atom to which theyare attached a non aromatic heterocyclic group, selected from R ishydrogen or halogen； R is phenyl, unsubstituted or substituted bycyano, halogen, lower alkyl, lower alkoxy, CF, -(CH)O-loweralkyl, C(O)-lower alkyl or C(O)O-lower alkyl, or is pyridinyl, unsubstitutedor substituted by CF, or is -C(O)-phenyl； Ris hydrogenor lower alkoxy； R is phenyl, lower alkyl or -C(O)O-lower alkyl； Ris hydrogen or S(O)-lower alkyl； R is hydrogen or cycloalkyl；X is -CH- or -C(O)-； p is 1 or 2； n is 1, 2 or 3； o is 1 or 2； or to a pharmaceuticallysuitable acid addition salt thereof which are high potential NK-3 receptor antagonistsfor the treatment of depression, pain, psychosis, Parkinson's disease,schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
