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מעכבי פרוטאז קטפסין s , יעילים בטיפול, לדוגמא בהפרעות אוטואימוניות, אלרגיה ומצבי כאב כרוני
专利权人:
MEDIVIR UK LIMITED
发明人:
申请号:
IL22306512
公开号:
IL223065A
申请日:
2012.11.15
申请国别(地区):
IL
年份:
2015
代理人:
摘要:
There is provided a process for the preparation of a compound of formula III, comprising the step of oxidising the compound of formula 2b wherein n is 2; R 2a and R 2b are independently H or F; R 3 is 1-methylcyclopentylmethyl or 1-fluorocyclopentylmethyl; R 3' is CH 3 or F; R 4 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or C 3 -C 6 cycloalkyl, wherein C 3 -C 6 cycloalkyl is optionally substituted with methyl, CF 3 or one or two fluoro. Compounds and processes used in the preparation of a compound of formula III are also provided.
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