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תרכובות 2–סולפונאמידופניל מותמרות n–אריל מותמרות פרופיאונאמיד, תהליכים להכנתן, תרופות המכילים אותן, ושימושים@בהן
专利权人:
GRUNENTHAL GMBH
发明人:
申请号:
IL21938012
公开号:
IL219380A
申请日:
2012.04.24
申请国别(地区):
IL
年份:
2013
代理人:
摘要:
Sulfonylamino-benzene derivatives (A), as pure stereoisomers (particularly enantiomers or diastereomers), racemates or mixtures in any proportions, optionally as salts and/or solvates are new. Sulfonylamino-benzene derivatives of formula (A), as pure stereoisomers (particularly enantiomers or diastereomers), racemates or mixtures in any proportions, optionally as salts and/or solvates are new. X : O, S or -NCN; Y : amino, NHR 30>;, NR 31>;R 32>;, or (un)saturated optionally substituted (OS) 1-10C aliphatic group; n : 0-4; R 1>;-R 4>;H, F, Cl, Br, I, SF 5, nitro, CF 3, CN, amino, OH, SH, CONH 2, SO 2NH 2, CONHOH, COOH, CHO, SO 2OH, NHR 11>;, NR 12>;R 13>;, OR 14>;, SR 15>;, CONHR 16>;, CONR 17>;R 18>;, SO 2NHR 19>;, SO 2NR 20>;R 21>;, COOR 22>;, COR 23>;, SOR 24>;, SO 2R 24>; or (un) saturated OS 1-10C aliphatic group; R 5>;R 1>;, CF 2Cl, or (un)saturated OS 3-9 membered cycloaliphatic ring, attached via C atom, optionally including 1 or more heteroatoms in the ring; either Q : a group of formula (a)-(g); R 6>;, R 7>;, R 9>;R 1>;, CF 2Cl, or OS 6-10 membered aryl, optionally attached via OS 1-6C alkylene, 2-6C alkenylene or 2-6C alkynylene; R 8>;R 1>;, CF 2Cl, amidino, C(=NH)-NHR 27>;, guanidino, or N=C(NHR 28>;)(NHR 29>;); or (un)saturated OS 3-9 membered cycloaliphatic ring, attached via C atom, optionally including 1 or more heteroatoms in the ring, optionally fused with (un)saturated OS mono- or poly-cyclic ring system and/or attached via OS 1-6C alkylene, 2-6C alkenylene or 2-6C alkynylene; or OS 5-14 membered (hetero)aryl group, optionally fused with (un)saturated OS mono- or poly-cyclic ring system and/or attached via OS 1-6C alkylene, 2-6C alkenylene or 2-6C alkynylene; R 10>;SF 5, nitro, CF3, CF2Cl, CN, amino, OH, SH, CONH2, SO2NH2, CONHOH, COOH, CHO, SO 2OH, NHR 11>;, NR 12>;R 13>;, OR 14>;, SR 15>;, CONHR 16>;, CONR 17>;R 18>;, SO 2NHR 19>;, SO 2NR 20>;R 21>;, COOR 22>;
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