ДЗЕ РИДЖЕНТС ОФ ДЗЕ ЮНИВЕРСИТИ ОФ КОЛОРАДО; Э БОДИ КОРПОРЕЙТ (US)
发明人:
ПАТЕЛ Маниша (US)
申请号：
RU2014126866
公开号：
RU2014126866A
申请日:
2012.12.03
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A method of treating a subject suffering from exposure to a chemical poisonous substance, comprising administering to said subject an effective amount of a compound selected from: a) a compound having the structure of formula (I) or formula (II), wherein R, R, R and R are each independently, are —CF, —COR, —COR, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R R each independently represents hydrogen, halogen, —CN, —CF, —OH, —NH, —COOH, —COOR, —CHCOOR, —CHCOOH, unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted cycloalkyl, not replacing nny or substituted heterocycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl； R is unsubstituted alkyl； and M is a metal； b) a compound having the structure of one of the formulas (X) - (XV), where R, R, R and R are independently - (CH) CHOX or - (CHCHO) X； m is 1-6； n is 3 -50； X is substituted or unsubstituted C1-6 alkyl； M is a metal； each A independently represents hydrogen or an electron withdrawing group； and c) a compound having the structure of one of formulas (XVI) to (XVII), wherein at least one of R or R, R or R, R or R or R or R is independently - (CH) CHOX or - (CHCHO) X； the other is from R or R, R or R, R or R or R or R is independently C 1-6 alkyl (straight or branched)； p is 1-6； q is 3-50； X is substituted or unsubstituted C 1-6 alkyl； M is a metal； each A independently represents hydrogen or an electron withdrawing group； wherein said chemical poisonous substance is an anticholinesterase agent, a GABA agent or metabolic poison. 2. The method of claim 1, wherein said compound1. Способ лечения субъекта, страдающего от воздействия химического отравляющего вещества, включающий введение указанному субъекту эффективного количества соединения, выбранного из:a) соединения, имеющего структуру формулы (I) или формулы (II),гдеR, R, Rи R, каждый независимо, представляют собой -CF, -COR, -COR,R, R, R, R, R, R, R, R, R, R, R
