A method and apparatus for collecting signals and a method and apparatus for tracking cells by using light sensitive chip, relate to the technical field of signal collection, wherein the method for collecting signals by using light sensitive chip comprises closely fitting a luminous surface of a membrane carrying optical signals to be collected on a light sensitive chip (101), placing the light sensitive chip fitted with the membrane carrying optical signals to be collected in a dark room (102), collecting optical signals (103) by the light sensitive chip in the dark room, and processing and outputting the collected optical signals (104). The method and apparatus for collecting signals by using the light sensitive chip can collect signals by contacting the light sensitive chip to convert optical signals into digital signals so as to complete quantitative analysis.