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NANOPULBERI DE HIDROXIAPATITĂ ŞI DERIVAŢII EI SUBSTITUIŢI, UTILIZATE ÎN SCOPURI MEDICALE ŞI PROCEDEU DE FABRICARE A ACESTORA
专利权人:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" DIN CLUJ-NAPOCA
发明人:
TOMOAIA GHEORGHE,TOMOAIA-COTISEL MARIA,POP LACRIMIOARA-BIANCA,MOCANU AURORA,POP ALEXANDRU,POP LĂCRIMIOARA-BIANCA
申请号:
RO201000523
公开号:
RO125817B1
申请日:
2010.06.14
申请国别(地区):
RO
年份:
2013
代理人:
摘要:
The invention relates to bioactive nanopowders to be employed in bone reconstructions and to a process for preparing the same. According to the invention, the nanopowders are presented as chemically and structurally homogeneous particles with high crystallinity and a diameter of less than 50 nm, where the substituting ions are 0.75-2% Mg, 0.01-0.5% Zn and 0.01-0.5% SiO. The claimed process consists in precipitating a hydroxyapatite suspension in emulsion, under vigorous stirring at a temperature of 40...80°C and a pH value of 9.5...11.5, at an inorganic phase : organic phase ratio of 1 : 2...4 of an emulsion containing soluble salts of Ca, Mg, Zn, SiOand PO, separating the precipitate, redispersing the same in water with addition of 0.1...0.5% phenol ethoxylate and cow's milk whey (Z) as a dispersing agent in a ratio of 1 : 1.5...2 m/m, separating the precipitate, redispersing the same in water in a ratio of 1 : 100...150 with addition of polyacrylic acid as a sintering preventing agent and Ca(OH)for precipitation, the precipitate being finally heat treated at a temperature of 600...1300°C, while removing CaO and organic compounds traces.
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