肝疾患治療用又は予防用の血中滞留型多相エマルション製剤及びその製造方法
- 专利权人:
- 宮崎県
- 发明人:
- 清水 正高,坪内 博仁,有森 和彦,山崎 啓之,西片 奈保子
- 申请号：
- JP2005317608
- 公开号：
- JP5028564B2
- 申请日:
- 2005.10.31
- 申请国别(地区):
- JP
- 年份:
- 2012
- 代理人:
- 摘要：
PROBLEM TO BE SOLVED: To develop a new pharmaceutical preparation capable of targeting to a target cell tissue part by using an emulsion type carrier (transporter) having high safety to living bodies in order to improve pharmacodynamic effects of a physiologically active substance having extremely rapid metabolism/loss rate and large risk of serious side effect.
SOLUTION: In the carrier targeting the hepatic parenchymal cell, a function which becomes the trinity of targeting utilizing (1) 50-300 nm particle diameter, (2) avoidance of reticuloendothelial system (RES) and (3) molecular chain (targeting ligand) specifically binding to a receptor is required. The subject (1) is solved by finding an epoch-making preparation technique of S/O suspension and S/O/W emulsion and the subject (2) is solved by searching a self-orientation type RES avoidance inducer suitable for emulsion preparation and developing the introduction technique and the subject (3) is solved by searching a self-orientation type liver parenchyma cell-orientating substance suitable for the emulsion preparation and developing the introduction technique.
COPYRIGHT: (C)2007,JPO&INPIT
- 来源网站：
- 中国工程科技知识中心
