(A) fatty acid triglyceride, (B) above 1 or 2 kinds of the glyceric acid fat ester of 18 (C) the rectum lower part stay characteristic base component, it is the rectum lower part stay type medicine which features that the medicine base which consists of is combined from carbon atom several 14, before the rectum inserting, the occasion where you keep with the finger, it does not melt at body temperature of the finger, handling is easy, it is the rectum lower part stay type medicine where the quite safety there is no deformation of the medicine with the temperature rise when retaining, furthermore, stimulus to the rectum mucous membrane prevents, is full and prevents bleeding and swelling Hari etc is high.(A)脂肪酸トリグリセリド、(B)炭素原子数14から18のグリセリン酸脂肪エステルの1種または2種以上(C)直腸下部滞留性基剤成分、からなる坐剤基剤を配合することを特徴とする直腸下部滞留型坐剤であり、直腸挿入前、指で保持した際、指の体温で融解せず、取り扱いが容易で、保存時の温度上昇による坐剤の変形が無く、更に、直腸粘膜への刺激を防止をして、充出血や腫張等を防止した極めて安全性の高い直腸下部滞留型坐剤である。