CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS

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专利权人:

发明人:

申请号：

EP16754372.7

公开号：

EP3334745A1

申请日:

2016.08.11

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

A class of polycyclic compounds of general formula (I), of general formula (I), or of general formula (I"), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

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