ALTMAN, Michael, D.,ANDRESEN, Brian,CHANG, Wonsuk,CHILDERS, Matthew Lloyd,CUMMING, Jared, N.,HAIDLE, Andrew Marc,HENDERSON, Timothy, J.,JEWELL, James, P.,LIANG, Rui,LIM, Jongwon,LIU, Hong,LU, Min,NORT
申请号：
PH12018500299
公开号：
PH12018500299A1
申请日:
2018.02.09
申请国别(地区):
PH
年份:
2018
代理人:
摘要：
A class of polycyclic compounds of general formula (I), of general formula (I), or of general formula (I"), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
