Michael D. Altman,Brian Andresen,Wonsuk Chang,Matthew Lloyd Childers,Jared N. Cumming,Andrew Marc Haidle,Timothy J. Henderson,James P. Jewell,Rui Liang,Jongwon Lim,Hong Liu,Min Lu,Alan B. Northrup,Rya
申请号：
US15886578
公开号：
US20180237469A1
申请日:
2018.02.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
