The invention relates to a drive device (1) for a wheelchair (2) comprising a control element (23), a chassis (9, 13) and a retaining frame (15). A fixing device (19) is mounted on the retaining frame (15) and can be fixed to a wheelchair frame (7) of the wheelchair (2). The fixing device (19) is designed such that it can be automatically connected to and released from the wheelchair frame (7) of the wheelchair (2) by a fixing drive (21).