A drive device (1) for a wheelchair (2) comprises a control element (23), a chassis (9, 13) and a support frame (15). A fixing arrangement (19) is mounted on the support frame (15) and can be fixed to a wheelchair frame (7) of the wheelchair (2). The fixing arrangement (19) is designed such that it can be automatically connected to and released from the wheelchair frame (7) of the wheelchair (2) by a fixing drive (21).