Else Marie Agger,Peter Andersen,Anja Olsen,Ida Rosenkrands
申请号：
US13083385
公开号：
US08241610B2
申请日:
2011.04.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides a vaccine adjuvant consisting of a combination of a surfactant i.e. dimethyldeoctadecylammonium-bromide/chloride (DDA) and a lipid extract from Mycobacterium bovis BCG. The total lipid extract contains both apolar lipids, polar lipids, and lipids of intermediate polarity of which the apolar lipids were found to induce the most powerful immune responses. The total lipids may be extracted with chloroform/methanol and re-dissolved in water before the addition of surfactant. This preparation may be used to induce prominent cell-mediated immune responses in a mammal in order to combat pathogens, or as a treatment for cancer.
