SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT

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专利权人:

MERCK SHARP & DOHME CORP.

发明人:

MILLER, MICHAEL, W.,STAMFORD, ANDREW, W.,BASU, KALLOL,GEISS, WILLIAM, B.,EDMONDSON, SCOTT, D.,GUO, ZHIQIANG

申请号：

EP12836652

公开号：

EP2760855A4

申请日:

2012.09.24

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

Substituted cyclopropyl compounds of the formula I and the pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the g-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included. Another aspect of the invention that is of interest relates to compounds of formula 1a.

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