LIM, HYUNG KYU,KIM, HYUN UK,LEE, MI KYOUNG,LEE, JONG SOO,BAE, SUNG MIN,KWON, SE CHANG
申请号：
EP13822545
公开号：
EP2877201A4
申请日:
2013.07.25
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention relates to a liquid formulation of a combination of long-acting insulin and insulinotropic peptide, comprising insulin which is a physiologically active peptide, insulinotropic peptide, and albumin-free stabilizer, wherein the stabilizer comprises a buffer, a sugar alcohol, a non-ionic surfactant, and an isotonic agent and a method for preparing the liquid formulation. The liquid formulation of the present invention does not contain a human serum albumin and potentially toxic factors to the body, and thus it has excellent storage stability for insulin conjugate and insulinotropic peptide conjugate at high concentration, without a risk of viral contamination.
