Hyung Kyu Lim,Hyun Uk Kim,Mi Kyoung Lee,Jong Soo Lee,Sung Min Bae,Se Chang Kwon
申请号：
US14416231
公开号：
US09833516B2
申请日:
2013.07.25
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a liquid formulation of a combination of long-acting insulin and insulinotropic peptide, comprising insulin which is a physiologically active peptide, insulinotropic peptide, and albumin-free stabilizer, wherein the stabilizer comprises a buffer, a sugar alcohol, a non-ionic surfactant, and an isotonic agent and a method for preparing the liquid formulation. The liquid formulation of the present invention does not contain a human serum albumin and potentially toxic factors to the body, and thus it has excellent storage stability for insulin conjugate and insulinotropic peptide conjugate at high concentration, without a risk of viral contamination.
