This disclosure relates to methods for improving neural function in a mammal with a proteinopathy comprising administering a therapeutically effective amount of an agent that increases glucocerebrosidase activity in the mammal_ Also disclosed are methods for reducing toxic lipids, reducing a-synuclein, and/or inhibiting the accumulation of protein aggregates in a mammaJ with a proteinopathy comprising administering a therapeutically effective amount of an agent that increases glucocerebrosidase activity.
