LIU, DINGJIANG,HUANG, HOLLY ZHUOHONG,MARTIN, DAVID ANDREW,RUSSELL, CHRISTOPHER BOYD,SALINGER, DAVID H.,BAUMGARTNER, SCOTT WALTER,ENDRES, CHRISTOPHER J.
申请号：
PE2012001003
公开号：
PE20121691A1
申请日:
2011.01.12
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
The invention relates to a pharmacological formula, which comprises a glutamate buffer and an antigen aqueous solution, including a heavy chain CDR1, which is composed of SEC ID No.5, a heavy chain CDR2, which is composed of SEC ID No.7, a heavy chain CDR3, which is composed of SEC ID No.8, One light chain CDR1, including ID No.9, one light chain CDR2, including ID No.10 and light chain CDR3 including ID No.11. The scarf consists of 5-30mm + / -0.2mm glucose acid concentration with a pH of 4.5-5.2 + / -0.2. This antibody or its fragment binds to the a receptor of IL-17 human bodyREFERIDA A UNA FORMULACION FARMACEUTICA QUE COMPRENDE UNA SOLUCION ACUOSA DE UN BUFFER DE ACIDO GLUTAMICO Y UN ANTICUERPO QUE COMPRENDE UNA CDR1 DE CADENA PESADA QUE COMPRENDE SEC ID Nº:5, UNA CDR2 DE CADENA PESADA QUE COMPRENDE SEC ID Nº:7, UNA CDR3 DE CADENA PESADA QUE COMPRENDE SEC ID Nº:8, UNA CDR1 DE CADENA LIVIANA QUE COMPRENDE SEC ID Nº:9, UNA CDR2 DE CADENA LIVIANA QUE COMPRENDE SEC ID Nº:10 Y UNA CDR3 DE CADENA LIVIANA QUE COMPRENDE SEC ID Nº:11. EL BUFFER COMPRENDE UNA CONCENTRACION DE ACIDO GLUTAMICO DE 5-30 mM +/- 0,2 mM Y TIENE UN PH DE 4,5-5,2 +/- 0,2. DICHO ANTICUERPO O FRAGMENTO DEL MISMO SE UNE AL RECEPTOR A DE IL-17 HUMANA
