Stabilized formulations containing anti-pcsk9 antibodies

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专利权人:

REGENERON PHARMACEUTICALS INC.

发明人:

WALSH SCOTT,DIX DANIEL

申请号：

NZ61937912

公开号：

NZ619379A

申请日:

2012.07.27

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Discloses a liquid pharmaceutical formulation comprising: (a) 50±7.5 mg/mL to 250±37.5 mg/mL of an antibody or antigen-binding fragment thereof that specifically binds human proprotein convertase subtilisin kexin-9 (PCSK9), wherein the antibody comprises a heavy chain complementarity determining region (HCDR) 1 of SEQ ID NO:2, an HCDR2 of SEQ ID NO:3, an HCDR3 of SEQ ID NO:4, a light chain complementarity determining region (LCDR) 1 of SEQ ID NO:6, an LCDR2 of SEQ ID NO:7, and an LCDR3 of SEQ ID NO:8； (b) 10±1.5 mM histidine (pH 6.0±0.3)； (c) 0.01±0.0015% w/v polysorbate 20； and (d) 10±1.5% sucrose.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/