A compound of formula (I): ** Formula ** in which X represents -NH-, -O- or a bond； Y represents alkanediyl (C1-C4)； Z represents O or S； n represents 0 or 1； R1 represents - (C4-C6) alkyl； - (C1-C4) alkyl which is mono-substituted with (C3-C6) cycloalkyl, (C1-C4) alkoxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted aryloxy, optionally substituted heteroaryloxy, arylalkoxy (C1 -C2) optionally substituted, optionally substituted heteroarylalkoxy (C1-C2), optionally substituted heteroarylsulfanyl or -NR8R9； - (C2-C4) alkenyl which is mono-substituted with optionally substituted aryl； - (C2-C4) alkynyl which is mono-substituted with optionally substituted aryl； - (C3-C6) cycloalkyl which is mono- or di-substituted with (C1-C4) alkyl, mono-substituted with (C1-C4) alkoxy, mono-substituted with optionally substituted aryl or mono-substituted with optionally substituted heteroaryl； - optionally substituted aryl； or - a partially unsaturated 10-member ring system； R2 represents hydrogen, (C1-C4) alkyl, (C1-C4) alkoxy, fluoroalkyl (C1-C4), halogen, alkylsulfonyl (C1-C4), phenylsulfonyl or alkylsulfonylamino (C1-C4)； R3 represents hydrogen, (C1-C4) alkoxy or halogen； R4 represents hydrogen, (C1-C4) alkoxy, halogen, (C1-C4) alkylsulfonyl, optionally substituted aryl or optionally substituted heteroaryl； R5 represents hydrogen, (C1-C4) alkyl, (C1-C4) alkoxy, fluoroalkyl (C1-C4), halogen, cyano, -CONH2, optionally substituted aryl, optionally substituted heteroaryl, (C1-C4) alkylsulfonyl or dimethylamino -sulfonyl； and R6 represents hydrogen or halogen； or R5 and R6 together form a methylenedioxy group； R7 represents hydrogen or methyl； R8 represents hydrogen or methyl； R9 represents optionally substituted aryl, optionally substituted arylsulfonyl or optionally substituted heteroarylsulfonyl； and R10 represents -C (O) OH, -C (O) NH-CN, -C (O) NH-OH, -C (O) NH-S (O) 2CF3 or optionally substituted hete
