Derivatives of pyrazine and its use in the treatment of neurological disorders

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专利权人:

NOVARTIS AG

发明人:

TINTELNOT-BLOMLEY, MARINA,VEENSTRA, SIEM JACOB

申请号：

ES10796064

公开号：

ES2445536T3

申请日:

2010.12.22

申请国别(地区):

ES

年份:

2014

代理人:

摘要：

A compound of formula (I), or a pharmaceutically acceptable salt thereof, in which R 1 is hydrogen, cyano, halogen, (C 1-8) alkyl, halogen (C 1-8) alkyl, (C 1-8) alkoxy, halogen-C1-8 alkoxy, alkylthio (C1-8), halogen alkylthio (C1-8), alkoxy (C1-8) -alkyl (C1-8), alkoxy (C1-8) -alkoxy (C1- 8), (C1-8) alkoxy (C1-8) alkylthio (C1-8) alkylthio (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) ) -alkylthio (C1-8), alkenyl (C2-8), or alkynyl (C2-8)； R2 is a non-aromatic aryl, heteroaryl or heterocyclic group G1, group G1 which is optionally substituted by 1 to 4 substituents independently selected from the group, consisting of cyano, amino, aminocarbonyl, halogen, (C1-8) alkyl, halogen-alkyl (C1-8), hydroxy, oxo, (C1-8) alkoxy, halogen (C1-8) alkoxy, (C1-8) alkylthio, halogen (C1-8) alkyl, (C1-8) alkoxy (C1-8), (C1-8) alkoxy (C1-8) alkoxy, (C1-8) alkoxy (C1-8) alkylthio (C1-8) alkylthio (C1-8) alkyl, alkylthio ( C1-8) -alkoxy (C1-8), alkylthio (C1-8) -alkylthio (C1-8), alkenyl (C2-8), alkynyl (C2-8), alkenoxy (C2-8), alkyloxy (C1 -8) and a cycloalkyl (C3-8), aryl, heteroaryl or non-aromatic heterocyclic group G2, group G2 which is optionally substituted by 1 to 4 substituents independently selected from the group, consisting of decian, aminocarbonyl, halogen, (C1-) alkyl 8), halogen (C1-8) alkyl, hydroxy, (C1-8) alkoxy, halogen (C1-8) alkoxy, (C1-8) alkylthio, halogen-al chylthio (C1-8), alkoxy (C1-8) -alkyl (C1-8), alkoxy (C1-8) -alkoxy (C1-8), alkoxy (C1-8) -alkylthio (C1-8), alkylthio (C1-8) -alkyl (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) -alkylthio (C1-8), alkenyl (C2-8) and alkynyl ( C2-8)； R3 is hydrogen, cyano, halogen, (C1-8) alkyl, halogen (C1-8) alkyl, (C1-8) alkoxy； halogen-C1-8 alkoxy, alkylthio (C1-8), halogen alkylthio (C1-8), alkoxy (C1-8) -alkyl (C1-8), alkoxy (C1-8) -alkoxy (C1- 8), (C1-8) alkoxy (C1-8) alkylthio (C1-8) alkylthio (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) ) -alkylthio (C1-8), alkenyl (C2-8), or alk

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