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1.5 - dihydro - 4 - pyrazolo [3,4-d] pyrimidin-2-yl onas and 1.5 - 4 - dihydro - 4 - 4.3 - pyrazolo [c] pyridin - 4 - onas as PDE1 inhibitors
专利权人:
H. LUNDBECK A/S
发明人:
申请号:
ARP170100915
公开号:
AR108109A1
申请日:
2017.04.10
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
1. Claim 1: a formula compound (1),where Y is N or CH; R¹ is selected from the group consisting of straight or branched C₂₋₈ alkyl, saturated monocyclic C₃₋₈ cycloalkyl, oxetanyl, tetrahydrofuranyl, and tetrahydropyranyl; all of which may be substituted, one or more times, with one or more substituents selected from the group consisting of methyl, fluorine, hydroxy, cyano or methoxy; R² is selected from the group consisting of linear or branched C₁₋₈-alkyl, phenyl, benzo [1,3] dioxol, and saturated monocyclic C₃₋₈-cycloalkyl; or R² is phenyl substituted one or more times with one or more substituents selected from the group consisting of halogen, C₁₋₃-alkyl and methoxy;or R² is pyridine substituted with a substituent selected from the group consisting of halogen, C₁₋₃-alkyl,C₁₋₃ alkoxy,Hydrogen fluoride c83218c83183323;C₃₋₄ cycloalkoxy and C₄₋₅ methylcycloalkoxy;or R² is selected from the group consisting of C miembros-alkyl-substituted 5-membered heteroaryls;R³ is selected from the group consisting of C₁₋₃ alkyl and saturated monocyclic C₃₋₈ cycloalkyl; each of which may be optionally substituted with a substituent selected from halogen, C₁₋₃ alkoxy,1. Phenyl, propylamine and oxetano; and the contained taurine and pharmaceutically acceptable salts.Reivindicación 1: Un compuesto de fórmula (1), donde Y es N o CH; R¹ se selecciona del grupo que consiste en alquilo C₂₋₈ lineal o ramificado, cicloalquilo C₃₋₈ monocíclico saturado, oxetanilo, tetrahidrofuranilo y tetrahidropiranilo; todos los cuales pueden estar sustituidos, una o más veces, con uno o más sustituyentes seleccionados del grupo consistente en metilo, flúor, hidroxi, ciano o metoxi; R² se selecciona del grupo consistente en alquilo C₁₋₈ lineal o ramificado, fenilo, benzo[1,3]dioxol y cicloalquilo C₃₋₈ monocíclico saturado; o R² es fenilo sustituido una o más veces con uno o más sustituyentes seleccionados del grupo consistente en halógeno, alquilo C₁₋₃ y metoxi; o R² es piridina sustituida con un sustituye
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