YOO, SANG KU,刘相九,劉相九,CHUNG, JIN WOOK,郑晋旭,鄭晉旭,JO, IN GEUN,曹仁根,IM, JEONG HO,林正浩,KANG, KU SUK,姜球锡,姜球錫,KIM, JIN YOUNG,金鎭暎
申请号：
TW103145316
公开号：
TWI585093B
申请日:
2014.12.24
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
Provided is a compound of the following Formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. Further, provided is a pharmaceutical composition for preventing or treating a metabolic syndrome or an inflammatory disease, including the same.in the formula, R1 is a hydrogen atom, methyl, methoxy, or a halogen atom； R2 is a hydrogen atom； a substituted or unsubstituted straight or branched C1-C6 alkyl group； a halogen atom； a substituted or unsubstituted straight or branched C1-C6 alkoxy group； or a substituted or unsubstituted straight or branched C1-C4 thioalkyl group； R3 and R4 are each independently a hydrogen atom, or a C1-C2 alkyl group； and in the case of the substituted alkyl, the substituted alkoxy, and the substituted thioalkyl, the substituent is a straight or branched C1-C5 alkyl group, a halogen atom, a straight or branched C1-C5 alkoxy group, or a straight or branched C1-C3 thioalkyl group.本發明提供一種式(I)化合物及其藥學上可接受之鹽類或溶劑化物(solvate)。進一步地，本發明提供一種包括該式(I)化合物且用於預防或治療代謝症候群或發炎性疾病的醫藥組成物。式(I)化合物中，R1係一氫原子、一甲基、一甲氧基、或一鹵原子；R2係一氫原子、一取代或未取代的直鏈或支鏈C1-C6烷基、一鹵原子、一取代或未取代的直鏈或支鏈C1-C6烷氧基、或一取代或未取代的直鏈或支鏈C1-C4硫烷基；R3及R4各獨立地係一氫原子、或一C1-C2烷基；以及當R2係取代的烷基、取代的烷氧基、取代的硫烷基時，該取代基係一直鏈或支鏈C1-C5烷基、一鹵原子、一直鏈或支鏈C1-C5烷氧基、或一直鏈或支鏈C1-C3硫烷基。
