DRYSDALE, MARTIN JAMES,DYMOCK, BRIAN WILLIAM,KRELL, CHRISTOPH,MUTZ, MICHAEL,PETERSEN, HOLGER,ZHENG, WEIJIA
申请号：
AT08717228
公开号：
AT552836T
申请日:
2008.02.28
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
The present invention relates to new salt forms of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, in particular the hydrochloride, tartrate, phosphate and hemi fumarate salt thereof； to crystalline forms of such salts； to polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide； to hydrates and polymorphs of the new salt forms mentioned above； to the use of the new salt forms mentioned above for the manufacture of a medicament for the treatment of a disorder mediated by Hsp90； to a method for treating a disorder mediated by Hsp90 using the new salt forms； to formulations comprising such salt forms, in particular aqueous solutions suitable for intravenous administration； and to amber glass containers being filled with such formulations.
