ACID ADDITION SALTS, HYDRATES AND POLYMORPHS OF 5-(2,4-DIHYDROXY-5-ISOPROPYL-PHENYL)-4-(4-MORPHOLIN-4-YLMETHYL-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE AND FORMULATIONS COMPRISING THESE FORMS
DRYSDALE, MARTIN JAMES,DYMOCK, BRIAN WILLIAM,KRELL, CHRISTOPH,MUTZ, MICHAEL,PETERSEN, HOLGER,ZHENG, WEIJIA
申请号：
NZ57885408
公开号：
NZ578854A
申请日:
2008.02.28
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed herein is 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morphonlin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide mesylate, in particular the crystalline form which has an X-ray diffraction pattern with peaks of about 8.0, 11.9, 13.9, 14.2, 16+.7, 18.5, 19.4, 22.7, 23.3 +/- 0.2 degrees 2è is preferred. Also disclosed are the hydrate forms HA and HB, preparation of said compounds in each form and an aqueous formulation comprising is 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morphonlin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide mesylate being free from any other salts having a pH between 3.2 and 5.2.
