Steven W. Andrews,James F. Blake,Adam Cook,Indrani W. Gunawardana,Kevin W. Hunt,Andrew T. Metcalf,David Moreno,Li Ren,Tony P. Tang
申请号:
US16276326
公开号:
US20190300511A1
申请日:
2019.02.14
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Provided herein are compounds of the general Formula I:and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which X, R1, R2, R3, Ring A and z have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, including diseases or disorders mediated by FGFR1, FGFR2, FGFR3 and/or FGFR4.