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Salts of an Epidermal Growth Factor Receptor Kinase Inhibitor
专利权人:
发明人:
Mei LAI,Andrew Roger ALLEN
申请号:
US14784503
公开号:
US20160074399A1
申请日:
2014.05.05
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same. Examples include hydrobromide and bis-besylate salts of N-(3-(2-(4-(4-acerylpiperazin-1-yl)-2-methoxyphenylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)phenyl)acrylamide). The salts and their polymorphs are evaluated for their properties such as stability, solubility, and pharmacokinetics.
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