A handle assembly and an anastomat comprising the same； the handle assembly includes a sliding chute (26) and a sliding block (3)； the sliding chute (26) is located on a second handle (2), and the sliding block (3) can move in the sliding chute (26)； when the sliding block (3) is located in a first section of the sliding chute (26), a first handle (1) and the second handle (2) are not linked； when the sliding block (3) is located in a second section of the sliding chute (26), the first handle (1) and the second handle (2) are linked by means of the sliding block (3), and drive the second handle (2) to move from a safety position to a triggering position； and the handle assembly is divided into the first handle (1) and the second handle (2), and only the movement of the second handle (2) can trigger the anastomat to perform incision and suture actions. During use, a doctor can press the first handle (1) regardless of whether the anastomat reaches the triggering position； however, the first handle (1) does not drive the second handle (2) when the anastomat does not reach a triggering state, and the anastomat thus cannot be triggered.
