HE, JIAN,MACNAIR, JOHN E.,SMITH, WILLIAM J.,WINTERS, MICHAEL A.,JOYCE, JOSEPH G.,ABEYGUNAWARDANA, CHITRANANDA,MUSEY, LUWY,PUJAR, HARI,SKINNER, JULIE M.,WEN, EMILY,MCHUGH, PATRICK,WILLIAMS, JOHN MICHAE
申请号：
CA3050120
公开号：
CA3050120A1
申请日:
2018.02.20
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
