Jian He,John E. MacNair,William J. Smith,Michael A. Winters,Joseph G. Joyce,Chitrananda Abeygunawardana,Luwy Musey,Hari Pujar,Julie M. Skinner,Emily Wen,Patrick McHugh,John Michael Williams,Catherine
申请号：
US16487550
公开号：
US20200054733A1
申请日:
2018.02.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
