He, Jian,Macnair, John, E.,Smith, William, J.,Winters, Michael, A.,Joyce, Joseph, G.,Abeygunawardana, Chitrananda,Musey, Luwy,Pujar, Hari,Skinner, Julie, M.,Wen, Emily,McHugh, Patrick,Williams, John M
申请号：
AU2018225099
公开号：
AU2018225099A1
申请日:
2018.02.20
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
