Paschalis Dimopoulos,Adrian Hall,Yoichi Kita,Andrew Madin,Nicola Louise Shuker
申请号：
US13978062
公开号：
US20140011802A1
申请日:
2012.01.05
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein R is hydrogen or C1-6 alkyl, optionally substituted by one to five halogen atoms n is 0, 1, 2 or 3 Ar is phenyl or a 5- or 6-membered heteroaromatic group containing 1, 2 or 3 N atoms, which Ar is optionally substituted by one to three substituents selected from hal, hydroxyl, —CN, C1-6alkyl, C2-3alkenyl, C2-3alkynyl,C-6alkoxy, C3-6cycloalkoxy and pyrazine, where C1-6alkyl and C1-6alkoxy are optionally substituted by one to three halogen atoms and pharmaceutically acceptable salts thereof which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease 1 caused by Aβ and typified by Alzheimer-type dementia.
