BLANKENSHIP, JOHN W.,SEWELL, ELAINE TODD,TAN, PHILIP
申请号：
CA2833019
公开号：
CA2833019A1
申请日:
2012.04.20
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane antigen (PSMA) and are useful for the treatment of prostate cancer (e.g., castrate-resistant prostate cancer), tumor-related angiogenesis or benign prostatic hyperplasia (BPH). In one embodiment, the multi-specific polypeptide therapeutics bind both PSMA-expressing cells and the T-cell receptor complex on T cells to induce target-dependent T-cell cytotoxicity, activation and proliferation.
