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ANTITUMORAL COMPOUNDS
专利权人:
PHARMA MAR; S.A.
发明人:
RODRIGUEZ VICENTE, ALBERTO,GARRANZO GARCIA-IBARROLA, MARIA,MURCIA PEREZ, CARMEN,SANCHEZ SANCHO, FRANCISCO,CUEVAS MARCHANTE, MARIA DEL CARMEN,MATEO URBANO, CRISTINA,DIGON JUAREZ, ISABEL
申请号:
NZ58601308
公开号:
NZ586013A
申请日:
2008.12.19
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a compound of general formula I wherein Y is selected from -CHRay-, -CHRay-CHRby-, -CRay=CRby-, -C=C-, -CHRay-CHRby-CHRcy-, -CHRay-CRby=CRcy-, and -CHRay-C=C- each Ray, Rby, and Rcy is independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl each R1, R2, R3, R4, and R5 is independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl R6 is selected from NR8R9, and OR10 A is as defined in the claims W is selected from O and NR7 R7 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl, or R7 and R5 together with the corresponding N atom and C atom to which they are attached may form a substituted or unsubstituted heterocyclic group R8 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, and substituted or unsubstituted C4-C12 alkenynyl R10 is selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl each dotted line represents an optional additional bond, but when a triple bond exists between the C atoms to which R1 and R2 are attached, R1 and R2 are absent, and when a triple bond exists between the C atoms to which R3 and R4 are attached, R3 and R4 are absent R9 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, and substituted or unsubstituted C4-C12 alkenynyl, with the proviso that when Y is -CHRayCHRby- CHRcy- or -CHRay-CRby=CRcy- and a single or a double bond exists bet
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