Refers to a compound of formula I, where z is CH or N g is Ciano, - C (o) nr15r16, - C (o) or17, R21, - C (o) - C (CH3) = nor22 b is a Ring or heterocycle carboxylic C5 - C12 R3 is H C1 - C7, halogen, alkyl R4 is H, alkyl or Halogen, C1 - C7 oxo M is C1 - C7 hydroxyl, alkyl - or NHR5 R5 h, Heterocyclic c5-c6, among others, R15 and R16, R17, h,Alkyl or cycloalkyl C1 - C3 - C7 C7 is heterocilico R21, R22 is H or alkyl C1 - C7. Preferred compounds are: N - (2 , 4 - difluoro - 5 - (5 - (1 - methyl - 1h-pyrazol-4-yl) - 1H benzo [d] imidazol-1-yl) biphenyl - 3 - il) acetamide n - (2 , 4 - difluoro - 5 - (5 - (1 - methyl - 1h-pyrazol-4-yl) - 1H benzo [d] imidazol-1-yl) biphenyl - 3 - il) metansulfonamida among others. It also relates to a Pharmaceutical composition.This Compound is an inhibitor of FGFR (Fibroblast Growth Factor receptor), useful in the treatment of cancer.SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE: Z ES CH O N G ES CIANO, -C(O)NR15R16, -C(O)OR17, -C(O)R21, -C(CH3)=NOR22 B ES UN ANILLO CARBOXILICO O HETEROCICLICO C5-C12 R3 ES H, HALOGENO, ALQUILO C1-C7, ENTRE OTROS R4 ES H, HALOGENO, ALQUILO C1-C7 U OXO M ES HIDROXILO, ALQUILO C1-C7 O -NHR5 R5 ES H, HETEROCICLICO C5-C6, ENTRE OTROS R15, R16 Y R17, SON H, ALQUILO C1-C7 O CICLOALQUILO C3-C7 R21 ES HETEROCILICO R22 ES H O ALQUILO C1-C7. SON COMPUESTOS PREFERIDOS: N-(2,4-DIFLUORO-5-(5-(1-METIL-1H-PIRAZOL-4-IL)-1H-BENZO[D]IMIDAZOL-1-IL)BIFENIL-3-IL)ACETAMIDA N-(2,4-DIFLUORO-5-(5-(1-METIL-1H-PIRAZOL-4-IL)-1H-BENZO[D]IMIDAZOL-1-IL)BIFENIL-3-IL)METANSULFONAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE FGFR (RECEPTOR DEL FACTOR DE CRECIMIENTO DEL FIBROBLASTO), UTIL EN EL TRATAMIENTO DEL CANCER.
