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Indazol compounds as FGFR cinasa inhibitors, preparation and use
专利权人:
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.;SHANGHAI INSTITUTE OF MATERIA MEDICA,CHINESE ACADEMY OF SCIENCES
发明人:
GENG, Meiyu,LIU, Lei,JIANG, Lei,HUANG, Min,ZHA, Chuantao,AL, Jing,WANG, Lei,CAO, Jianhua,DING, Jian
申请号:
PE2017000231
公开号:
PE20170774A1
申请日:
2015.08.19
申请国别(地区):
PE
年份:
2017
代理人:
摘要:
It refers to compounds of formula I, where: L is H or tetrahydropyranyl; X is Cl, F, H or CN; W, Y and Z are N or CH; ring A is absent or is a substituted or unsubstituted 5- to 8-membered arylene group, among others; R is H or any of the groups i, ii, among others; M is substituted or unsubstituted C1-C6 alkylene, among others. Preferred compounds are: N- (6- (2,6-dichloro-3,5-dimethoxyphenyl) -1H-indazol-3-yl) -4- (4-methylpiperazin-1-yl) benzamide; N- (6- (2,6-dichloro-3,5-dimethoxyphenyl) -1H-indazol-3-yl) -4-morpholino-benzamide; 4 - ((4-acetyl-1-yl) methyl) -N- (6- (2,6-dichloro-3,5-dimethoxyphenyl) -1H-indazol-3-yl) benzamide;There are others He also mentioned a method of production These compounds are made of indazol inhibitors of alpha HCH and beta HCH Streptococcus, which are used to treat intrauterine cancer, breast cancer, etc.Se refiere a compuestos de formula I, donde: L es H o tetrahidropiranilo; X es Cl, F, H o CN; W, Y y Z son N o CH; el anillo A esta ausente o es un grupo arileno de 5 a 8 miembros sustituidos o no sustituidos, entre otros; R es H o cualquiera de los grupos i, ii, entre otros; M es alquileno C1-C6 sustituido o no sustituido, entre otros. Son compuestos preferidos: N-(6-(2,6-dicloro-3,5-dimetoxifenil)-1H-indazol-3-il)-4-(4-metilpiperazin-1-il)benzamida; N-(6-(2,6-dicloro-3,5-dimetoxifenil)-1H-indazol-3-il)-4-morfolino-benzamida; 4-((4-acetil-1-il)metil)-N-(6-(2,6-dicloro-3,5-dimetoxifenil)-1H-indazol-3-il)benzamida; entre otros. Tambien se refiere a un metodo de produccion. Dichos compuestos son derivados de indazol inhibidores de la cinasa FGFR, siendo utiles en el tratamiento de cancer endometrial, cancer de mama, entre otros
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