The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment of sub-clinical PCV2 infection in animals, preferably in pigs.本發明係關於包含豬第二型環狀病毒(PCV2)抗原之免疫原性組合物用於預防及治療動物(較佳為豬)臨床無症狀之PCV2感染之用途。